Chinese Journal of Hospital Pharmacy

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Immunotherapeutic effect of dendritic cell vaccine assisted by Glycyrrhiza inflata polysaccharides in H22 hepatoma-bearing mice

YU Yongting, NADIREMU Xiaokelati, LU Yongqiang, ZHOU Zhaoxi, CONG Yuanyuan

Chinese Journal of Hospital Pharmacy, 2024, 44(1): 35-41. DOI: 10.13286/j.1001-5213.2024.01.06

组别	Bax/%	Bcl-2/%	Bax/Bcl-2
模型组（n＝10）	37.14±3.43	41.37±4.91	0.91±0.12
阳性组（n＝7）	40.94±1.13^a	33.79±5.84^a	1.26±0.34
TNF-α组（n＝10）	46.57±2.92^b	35.91±4.98	1.32±0.20
DC组（n＝10）	38.88±2.87	32.78±8.58^a	1.31±0.56
GiP组（n＝10）	44.56±5.11^b	29.30±7.57^b	1.65±0.58^b
GiP-B1组（n＝10）	39.86±4.05	22.74±9.99^b	2.02±0.76^b

Tab 5 Effect of DC vaccine assisted by Glycyrrhiza inflata polysaccharide on the expression of Bax and Bcl-2 protein in tumor tissues（$\bar{x}±s$）

Other figure/table from this article

Fig 1 Morphological changes of BMDC during culture （×200）
Fig 2 Form of DC vaccine in each group （×200）
Tab 1 Expression of the surface marker molecules of DC vaccine in each group （%，n＝3，$\bar{x}±s$）
Fig 3 Expression of the surface marker molecules of Glycyrrhiza uralensis polysaccharide-assisted DC vaccine
Fig 4 Changes of the body mass of tumor-bearing mice in each group during immunotherapy 注（note）：与模型组相比（vs. model group），^aP<0.05，^bP<0.01。
Tab 2 Effects of immunotherapy on tumor weight， tumor volume and tumor inhibition rate in tumor-bearing mice （$\bar{x}±s$）
Fig 5 The tumor photos of tumor-bearing mice in each group during inmunotherapy
Tab 3 Effect of immunotherapy on the organ index of tumor-bearing mice （mg·g^–1，$\bar{x}±s$）
Tab 4 Effect of immunotherapy on the content of cytokines in tumor-bearing mice （$\bar{x}±s$）
Fig 6 Effect of Glycyrrhiza inflata polysaccharide-assisted DC vaccine on liver tissue of tumor-bearing mice （×200）
Fig 7 Effect of Glycyrrhiza uralensis polysaccharide-assisted DC vaccine on tumor tissue of tumor-bearing mice （×200）
Fig 8 Effect of Glycyrrhiza inflata polysaccharide-assisted DC vaccine on the expression of Bax in tumor tissue of tumor-bearing mice （×400）
Fig 9 Effect of Glycyrrhiza inflata polysaccharide-assisted DC vaccine on the expression of Bcl-2 in tumor tissue of tumor-bearing mice （×400）

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