Chinese Journal of Hospital Pharmacy

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Immunotherapeutic effect of dendritic cell vaccine assisted by Glycyrrhiza inflata polysaccharides in H22 hepatoma-bearing mice

YU Yongting, NADIREMU Xiaokelati, LU Yongqiang, ZHOU Zhaoxi, CONG Yuanyuan

Chinese Journal of Hospital Pharmacy, 2024, 44(1): 35-41. DOI: 10.13286/j.1001-5213.2024.01.06

组别	CD11c	CD80	CD86	MHC-Ⅱ
Control组	50.17±0.76	26.80±3.90	48.87±2.64	50.30±2.19
DC组	52.00±1.21	34.03±0.32^a	57.50±5.64^a	65.03±2.11^b
TNF-α组	51.63±0.83	41.37±4.81^bc	76.37±3.19^bd	83.23±5.97^bd
GiP组	51.97±1.58	55.07±1.31^bd	74.20±2.21^bd	77.3±6.08^bd
GiP-B1组	53.33±1.79	57.57±6.06^bd	76.37±2.41^bd	85.80±2.46^bd

Tab 1 Expression of the surface marker molecules of DC vaccine in each group （%，n＝3，$\bar{x}±s$）

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Fig 1 Morphological changes of BMDC during culture （×200）
Fig 2 Form of DC vaccine in each group （×200）
Fig 3 Expression of the surface marker molecules of Glycyrrhiza uralensis polysaccharide-assisted DC vaccine
Fig 4 Changes of the body mass of tumor-bearing mice in each group during immunotherapy 注（note）：与模型组相比（vs. model group），^aP<0.05，^bP<0.01。
Tab 2 Effects of immunotherapy on tumor weight， tumor volume and tumor inhibition rate in tumor-bearing mice （$\bar{x}±s$）
Fig 5 The tumor photos of tumor-bearing mice in each group during inmunotherapy
Tab 3 Effect of immunotherapy on the organ index of tumor-bearing mice （mg·g^–1，$\bar{x}±s$）
Tab 4 Effect of immunotherapy on the content of cytokines in tumor-bearing mice （$\bar{x}±s$）
Fig 6 Effect of Glycyrrhiza inflata polysaccharide-assisted DC vaccine on liver tissue of tumor-bearing mice （×200）
Fig 7 Effect of Glycyrrhiza uralensis polysaccharide-assisted DC vaccine on tumor tissue of tumor-bearing mice （×200）
Fig 8 Effect of Glycyrrhiza inflata polysaccharide-assisted DC vaccine on the expression of Bax in tumor tissue of tumor-bearing mice （×400）
Fig 9 Effect of Glycyrrhiza inflata polysaccharide-assisted DC vaccine on the expression of Bcl-2 in tumor tissue of tumor-bearing mice （×400）
Tab 5 Effect of DC vaccine assisted by Glycyrrhiza inflata polysaccharide on the expression of Bax and Bcl-2 protein in tumor tissues（$\bar{x}±s$）

模态框（Modal）标题

Figure/Table detail