Chinese Journal of Hospital Pharmacy

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Immunotherapeutic effect of dendritic cell vaccine assisted by Glycyrrhiza inflata polysaccharides in H22 hepatoma-bearing mice

YU Yongting, NADIREMU Xiaokelati, LU Yongqiang, ZHOU Zhaoxi, CONG Yuanyuan

Chinese Journal of Hospital Pharmacy, 2024, 44(1): 35-41. DOI: 10.13286/j.1001-5213.2024.01.06

组别	IL-12（P70）/（ng·mL^-1）	IFN-γ/（pg·mL^-1）	IL-10/ （pg·mL^-1）	IL-4/ （pg·mL^-1）
模型组（n＝10）	3.29±1.08	237.81±65.65	36.8±7.66	39.06±4.11
阳性组（n＝7）	1.23±0.46^b	102.37±39.43^b	24.09±4.08^b	26.09±6.40^b
TNF-α组（n＝10）	3.36±1.17	289.53±134.88	26.7±3.58^b	34.24±7.89
DC组（n＝10）	5.02±1.85^b	325.35±80.96^a	22.08±6.75^b	34.09±14.86
GiP组（n＝10）	5.32±0.74^b	333.71±62.78^a	25.94±4.42^b	31.36±8.14^a
GiP-B1组（n＝10）	5.99±1.57^b	388.82±94.81^b	23.02±5.12^b	29.82±4.60^b

Tab 4 Effect of immunotherapy on the content of cytokines in tumor-bearing mice （$\bar{x}±s$）

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Fig 1 Morphological changes of BMDC during culture （×200）
Fig 2 Form of DC vaccine in each group （×200）
Tab 1 Expression of the surface marker molecules of DC vaccine in each group （%，n＝3，$\bar{x}±s$）
Fig 3 Expression of the surface marker molecules of Glycyrrhiza uralensis polysaccharide-assisted DC vaccine
Fig 4 Changes of the body mass of tumor-bearing mice in each group during immunotherapy 注（note）：与模型组相比（vs. model group），^aP<0.05，^bP<0.01。
Tab 2 Effects of immunotherapy on tumor weight， tumor volume and tumor inhibition rate in tumor-bearing mice （$\bar{x}±s$）
Fig 5 The tumor photos of tumor-bearing mice in each group during inmunotherapy
Tab 3 Effect of immunotherapy on the organ index of tumor-bearing mice （mg·g^–1，$\bar{x}±s$）
Fig 6 Effect of Glycyrrhiza inflata polysaccharide-assisted DC vaccine on liver tissue of tumor-bearing mice （×200）
Fig 7 Effect of Glycyrrhiza uralensis polysaccharide-assisted DC vaccine on tumor tissue of tumor-bearing mice （×200）
Fig 8 Effect of Glycyrrhiza inflata polysaccharide-assisted DC vaccine on the expression of Bax in tumor tissue of tumor-bearing mice （×400）
Fig 9 Effect of Glycyrrhiza inflata polysaccharide-assisted DC vaccine on the expression of Bcl-2 in tumor tissue of tumor-bearing mice （×400）
Tab 5 Effect of DC vaccine assisted by Glycyrrhiza inflata polysaccharide on the expression of Bax and Bcl-2 protein in tumor tissues（$\bar{x}±s$）

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